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One other important result was that patients treated with a single dose of prednisolone were statistically more likely to receive additional doses of the steroid compared to patients treated with 0.25 mg/m2 of prednisolone. This finding is in line with some human studies reporting that repeated doses of prednisolone (in combination with nifedipine hydrochloride) could reduce the incidence of relapse or adverse events associated with multiple-dose steroids [23].
In a recent meta-analysis, one thousand six hundred and sixty-five subjects with chronic intermittent fever (CIFL) were randomly assigned to receive prednisolone at the initial dose (1.0 mg/m2 for four days with 2 mg/m2 to be withdrawn at the fourth day), placebo, or no treatment (which did not include nifedipine hydrochloride or a combination of prednisolone and nifedipine). The primary outcome was frequency of CIFL occurrence and the secondary outcome was reduction in the rate of worsening of the condition, what is better sarms or prohormones. Patients randomized to the prednisolone trial had an incidence of the most severe CIFL of 12, xepasone prednisolone.5% and significantly poorer outcomes than those in the placebo group (odds ratio (OR): 0, xepasone prednisolone.49, 95% confidence interval (CI): 0, xepasone prednisolone.28–0, xepasone prednisolone.89; p-trend = 0, xepasone prednisolone.0002), xepasone prednisolone. At the end of the treatment, the rate of worsening of the condition was 10.5% higher in the prednisolone group, indicating that there was a significant reduction, although there was not a difference between the various interventions in their effect on adverse effects. This suggests that the prednisolone treatment of CIFL caused a significant reduction in the severity of the disease over the course of the treatment, which is consistent with other studies that indicate that some subjects may be in remission when treated with prednisolone [8].
A single dose of prednisolone is a safe and feasible therapy for patients who have a severe CIFL for up to 7 days, and an alternative to a combination of prednisolone and nifedipine hydrochloride is a single dose of prednisone plus oral nifedipine hydrochloride for up to 28 days [24], prednisolone xepasone. Moreover, it has proven to be an effective adjuvant therapy in some studies with subclinical chronic intermittent fever; however, other studies have shown that prednisolone, compared to placebo, does not reduce the risk of relapse [8].
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