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Ibutamoren mesylate (5 mg/kg/day) results in a statistically significant increases body weight gain and increases serum igf-1 and gh levels in dogs. Mk-677 increases growth hormone without replacing, it safely and is available as a troche or capsule. Mk-677 increases lean muscle mass, improves sleep, and. Mk-677 - also known as ibutamoren or nutrobal - was originally developed as a drug to treat serious conditions associated with muscle atrophy (. The ibutamoren mesylate (mk677) is commonly known as a non-peptide growth hormone secretagogue that mimics ghrelin's stimulation action. Ibutamoren increases levels, by mimicking the action of the hormone ghrelin , and binding to one of the ghrelin receptors in the brain ). Ibutamoren mesylate (mk-0677), an orally active nonpeptide growth hormone (gh) secretagogue, stimulates gh release through a pituitary and hypothalamic. 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